The Cardinals had knocked off four straight higher seeds but this wasn't meant to be.
UConn's Brenna Stewart scored 18 of her 23 points in the first half as the Huskers won their eight national title in the most lopsided victory in a title game.The title tied Auriemma and the Huskies (35-4) with Pat Summitt and Tennessee for the most in women's basketball history.
The Cardinals led 14-10 but then fell behind 48-29 at halftime before UConn came out and hit 11 of its first 15 shots in the second half.
Connecticut hit 13 of 26 from the three-point line, while hitting 35 of 66 overall. U of L (29-9) hit 23 of 62 and just 5 of 23 three-pointers.
The Cardinals played in front of U of L men's basketball coach Rick Pitino - one night after winning a national title - and his entire staff. U of L football coach Charlie Strong was also in attendance at the game.
"We ran into a great team," U of L coach Jeff Walz said. "But I couldn't be prouder of a group of girls. I'm so proud of them."
Sara Hammond led U of L with 15 points and five rebounds, while Shoni Schimmel had nine on 3 of 15 from the field.