U of L (51-13) was shutout for just the second time this season and the first since the opening game of the season.
It just so happens that shutout was a 2-0 loss to Indiana and DeNato.
The Cardinals managed hits in the third, fifth, sixth and eighth innings. But the Cardinals had two runners thrown out at second trying to steal and a third - Sutton Whiting - gunned down at home after Cole Sturgeon's single in the third.
U of L starter Chad Green (10-4) lasted just two innings and gave up both runs, allowing four hits and walking four batters.
Cody Ege, Dace Kime and Cole Sturgeon kept the Hoosiers scoreless for the final six innings but the offense never woke up.
The loss was the third in four games this season against the Hoosiers.
The Cardinals now face an elimination game on Monday afternoon at 3 o'clock against Oregon State, a loser to Mississippi State on Saturday.