U of L coach Charlie Strong said Dominique Brown and Michael Dyer, along with Corvin Lamb, will all see action but confirmed that Perry will be on the field for the first play of the game for the Cardinals.
"When we trot out there for that first play, Senorise will trout out there with the first offense," Strong said.
U of L offensive coordinator Shawn Watson recently called Perry a "freak" for his quick recovery, comparing him to NFL star Adrian Peterson.
It's amazing the training camp he had," Strong said of Perry. "You would have never thought he had a knee injury at all. The way he cuts and plants.
"He's pretty amazing that's for sure."
Perry was the top back in the rotation with Jeremy Wright when he was injured last season. He carried for 705 yards – which led the team at the time he went down with the injury against Syracuse.
Strong said Watson will decide on who gets the carries and when, noting he wants to "eventually think" one feature back will step forward.
Perry went down with the injury on Nov. 10. He said a month before fall camp started that he was going to be back at the start of practice and he was. The staff held him out of several practices – mainly the second ones on two-a-days – just for precautionary reasons.
"We wanted to make sure he was here for the long haul," Strong said.