>The Houston Cougars opened the game with a 61-yard kickoff return to start their first drive at the Louisville 39 yard line. The Cardinals defense turn the Cougars over on downs, taking possession at own 23. Dominique Brown dominated the in resulting drive, rushing 6 times for 42 yards, including a 14-yard touchdown run for the game's first score. Louisville 7-0.
>After being held scoreless in first quarter and trailing 10-0, the Cougars managed a 10 play, 60 yard drive to tie game with 6:35 left in first half. The biggest play of the drive came on the first play, when John O'Korn hit Daniel Spencer for a 20-yard pass to the Cardinals 40. The Cougars then dink-and-dunked their way to the end zone to the tie the game on a 4-yard touchdown run. 10-10.
>Late in the second half and following a strong defensive stand, which included Lorenzo Mauldin's ninth sack on the season, Michaelee Harris muffed the resulting punt at the Louisville 39 yard line with 4 minutes remaining in first half. The Cougars converted the miscue into a 22-yard field goal to take a 13-10 halftime lead. The drive would have ended on an interception by safety Hakeem Smith but it was negated when a roughing the quarterback penalty was called against the Cardinals. It was the first time Louisville has trailed in the first half this season. Houston 13-10.
>Louisville regained the lead when it took the opening drive of the second half 70 yards on 7 plays for a 3-yard touchdown run by Brown. Brown rushed for 25 yards on 5 carries on the drive. The key moment of the drive came when Teddy Bridgewater connected with DeVante Parker on a 39-yard pass to the Houston 3 yard line. Louisville 17-13.
>Midway through the fourth quarter and holding just a one touchdown lead, the Cardinals defense was called upon to stop the Cougars once again. With 8 minutes remaining in the contest, Houston began the drive at it's own 27. The Cougars drove the ball to near midfield, when the combination of a strong pass rush and great coverage resulted in the end of the threat. The key moment came when defensive lineman Roy Philon read a 3rd & 10 screen pass perfectly and teamed up with safety Hakeem Smith for a 6-yard loss. Louisville 20-13.