Smith, who led the nation in sacks as a senior, played defensive end at U of L but has been switched to outside linebacker for the all-star game. The kickoff is set for 4 p.m.
The Senior Bowl is televised on the NFL Network. Smith will be No. 90 on the North.
A consensus All-American as a defensive end, Smith finished his senior season with 15 sacks. He had 25 sacks and 35 tackles for a loss during his career with the Cardinals.
Smith led the U of L defense, which allowed an FBS low in rushing yards this season, and helped the Cardinals finish 12-1 with a win over Miami in the Russell Athletic Bowl.