Ware confirmed the news to ESPN.com and then Louisville coach Rick Pitino confirmed that he will transfer with Cardinal Authority.
"We wish Kevin Godspeed," Pitino said.
Ware gained national attention last season in the Elite Eight win over Duke after suffering a gruesome broken leg. He became a national story after the injury and U of L's subsequent run to the school's third national title.
After a summer of rehabilitation, Ware made his return on Nov. 6 against Pikeville College. He made his first field-goal - a three-pointer - that he attempted in his return. In the third game of the regular-season, Ware scored five points in 13 minutes against Cornell.
Ware also played 13 minutes against Hartford on Nov. 19 and had four points but never played more than nine minutes in a game the rest of the season and combined for a total of six more points in seven more games.
Ware averaged just 1.7 points in nine games before suffering an injury to the same right leg in a Dec. 17 game against Missouri State.
At the time, he said he was going to seek a medical redshirt. He played a total of 53 minutes.
Ware is expected to transfer closer to his family in Atlanta with Auburn and Bruce Pearl - who signed him at Tennessee out of high school - the new coach of the Tigers.
In 66 career games, Ware scored 202 points and had 85 rebounds, 49 steals and 43 assists. He averaged 11.7 minutes a game and 3.1 points.