Pryor, who left U of L after three seasons, became just the ninth player in U of L history selected in the first round of the NFL Draft. He was picked at No. 18 by the New York Jets.
The 5-foot-11, 210-pound Pryor was the first safety to come off the board and joins three other former U of L players on the roster with the Jets - Bilal Powell, Breno Giacomini and Johnny Patrick.
Pryor had always been considered a late first or second-round pick but moved up in the eyes of many teams after his sensational NFL Combine and then another good day at his Pro Day.
The New York Times after the pick said: "The fit should be a good one for the Jets -- a team that will probably ask Pryor to do a whole lot of different things. He'll play in the box, where many believe he excels, but he's also likely to get some time in the back end as a "centerfielder" for the Jets' D."
Pryor had a stellar junior season with the Cardinals with 75 tackles and three interceptions. He finished his career with 218 tackles, seven interceptions and 21 pass deflections for the Cardinals.
"He will hit you and hurt you," ESPN's Mel Kiper said of Pryor.