Parker, who was injured in Friday's scrimmage, has a broken bone in the small toe on his left foot. He's expected to miss six to eight weeks, according to U of L coach Bobby Petrino.
"They timeline they gave to me is six to eight weeks," Petrino said, noting Dr. Bob Anderson was doing the surgery on Charlotte. He's the Carolina Panthers team doctor and is the doctor the NFL teams use at the Draft Combine to answer questions about the health of players.
Petrino said Parker went to North Carolina with a member of the U of L training staff and his family on Sunday.
The Cardinals must move on now without their big playmaker for the next month or two, but Petrino said the team has depth.
"Guys have to step up and perform," he said. "We’re fortunate in our situation that we have a lot of experienced players (at WR)."
The 6-foot-3 totaled 55 receptions for a team-high 885 yards and tied a school record with 12 touchdowns last season.
Earlier this summer, Parker was named to the Biletnikoff and Maxwell Awards preseason watch lists.
The Cardinals are scheduled to face Miami on Sept. 1 at 8 p.m. at Papa John’s Cardinal Stadium.