Mariya Moore had 11 points and 10 assists, Myisha Hines-Allen scored 18 and No. 12 Louisville beat Lafayette 102-61 on Friday night.
The Cardinals (6-0) out-rebounded Lafayette 20-4 on the offensive glass, forced 22 turnovers and edged the Leopards in shot attempts (75-49) as a result.
Hines-Allen made the most of the extra chances with 9-of-13 shooting. Louisville was 39 of 75 overall and 5 of 10 from 3-point range.
Lafayette (3-2) led 20-18 on Jamie O'Hare's 3-pointer midway through the first half, but the Cardinals took the lead for good with a 28-2 run.
O'Hare was 4 of 8 from 3-point range with 20 points to lead the Leopards. Emily Homan chipped in 12 points and seven rebounds.
Jude Schimmel was 4 of 5 from 3-point range with 15 points for Louisville. Emmonnie Henderson scored 13, Sara Hammond and Megan Deines had 11 apiece, and Bria Smith 10.