"I like it because they have great tradition and I think it's an opportunity for us to go into environments that are very good," Pitino told Cardinal Authority on Thursday. "So why start somewhere else when you have a tremendous program right in the state.
"It's always a good test for us."
The No. 4 Cardinals (9-0) will play the Hilltoppers (5-4) on Saturday at noon in the first true road game of the season.
The series would be tied at 39 wins with a Louisville victory on Saturday. The first game in the series was in 1926 but U of L has won five in a row and 22 of the past 25.
The game for U of L also comes six days after a sloppy effort in a win over UNC Wilmington. Pitino said he was "pleased" with the effort in practice this week.
"If we play anything close to Wilmington then we will get beat by 10 points," Pitino said. "We have to get back to the way we were playing against Ohio State and Indiana.
"I think they just got caught with an 18-point lead and relaxed. I think that's all that happened was they just relaxed."
The contract of the series between the two schools is up after this game, but it appears U of L will try to renew the series for next year.