The University of Louisville is in the East Region but the Cardinals will be headed out West for the first round of the NCAA Tournament.
The Cardinals (24-8) earned the No. 4 seed in the East Region and will open on Friday night against UC Irvine in the Seattle portion of the bracket.
"We're real happy about being out in Seattle," Louisville coach Rick Pitino told ESPN Radio on Sunday. "We wanted to get away. It's less distractions."
The winner of the U of L-UC Irvine game will play the winner of the Northern Iowa-Wyoming game in the second round.
Villanova is the No. 1 seed in the East Region with Virginia as the No. 2 seed.
The tip times for each game will be announced later on Sunday.
The Cardinals are joined in the rest of the East Region - where the Sweet 16 and Elite Eight game will be played in Syracuse - by No. 2 seed Virginia and No. 3 seed Oklahoma. A third ACC team - North Carolina State - is the No. 8 seed.
"Louisville is a strong team without Chris Jones, will still be a strong team as they move forward," NCAA Selection Committee chair Scott Barnes said. "No bad losses there."
Barnes said the selection committee took a long look at U of L's six games without Jones. The situation for the Cardinals was unique after Jones was dismissed. The Cardinals went 4-2 with a win over Virginia.
But the Cardinals did lose to North Carolina in the opening round of the ACC Tournament on Thursday. The Tar Heels ended up also being a No. 4 seed.
U of L was ranked No. 15 on the committee's seed list.
The Cardinals are in the NCAA Tournament for a ninth straight season and 41st time overall. U of L has 72 all-time wins in the NCAA Tournament, while they are tied for fourth in NCAA Sweet 16 appearances (20), sixth in advancing to Elite Eights (13) and seventh with 10 Final Fours. The Cardinals won the title in 1980, '86 and 2013.
"We had been to five straight conference championship games over the last five years," Pitino said in a release. "While we are disappointed that we did not advance in the ACC Tournament, the silver lining is that we had time to practice and work on a few different things. We feel that we're playing our best basketball of the season and are looking forward to a great tournament."
Season ticket holders who submitted NCAA post-season ticket requests online will contacted by via email on Sunday with details on purchasing their seats. Those season ticket holders will be notified later where the tickets will be available for pickup in Seattle. Student ticket information will be distributed via email to students on Monday.