In the end, a trip to the Final Four wasn't in the Cards.
Louisville played a stellar first half against Michigan State on Sunday in the East Region final and then fell victim to what has happened so many times this season - poor shooting.
The Cardinals hit just 6 of 32 from the field in the second half and overtime and saw the season come to an end with a 76-70 loss to Michigan State before 24,404 fans at the Carrier Dome. The Cardinals season ends at 27-9.
"Sometimes it can be a cruel game," U of L coach Rick Pitino said.
Senior guard Travis Trice scored 17 points to lead No. 7 seed Michigan State past the Cardinals and into the Final Four.
The Spartans (27-11) won for a 12th time in the past 15 games and two of those three losses are to Wisconsin, which is also in the Final Four.
Wayne Blackshear led the Cardinals in his final game with 28 points. He was 6 of 13 from the field and 12 of 12 from the free-throw line. He was vomiting at halftime and received a bloody nose in the second half.
The Spartans rallied from a 40-32 halftime deficit to eventually build a 61-59 lead with 3:57 left in the game. But U of L had a shot to win it in regulation.
With the ball and 12 seconds left, Terry Rozier drove the right side of the lane and missed a runner. Montrezl Harrell tipped it and Mangok Mathiang picked it up and went back. The ball rolled off the rim but he was fouled.
Down 65-64, Mathiang made 1 of 2 with 4.9 seconds left to force overtime.
But Michigan State took control in overtime, starting with Bryn Forbes hitting a three-pointer on the Spartans first possession. Branden Dawson sealed it with a putback in the final 31 seconds to put Michigan State up 74-70.
Louisville turned it over with 10 seconds left.
And the run was over.
Rozier finished just 6 of 23 from the field for 13 points, while Quentin Snider was 2 of 9 for four points. Harrell missed his final five shots and had 16 points and nine boards.