The two schools are playing the first of a two-year contract. U of L will play at Houston next season.
It will mark the 16th time the schools have played, dating back to 1950. Louisville has won six of the past seven meetings, including a 20-13 win in 2013 when the Cardinals played one season in the American Athletic Conference.
The two meetings prior to '13 came in 2003 and '04 when the Bobby Petrino-led Cardinals scored 60-plus points in both games to whip the Cougars two years in a row. U of L won 66-45 in '03 and 65-27 in '04.
Overall, Louisville leads the series 8-7 and has averaged 28.4 points a game against the Cougars.
The schools have played at least one time in every decade since 1950 except the 1970s. Houston won the first meeting 27-7 in 1950 and captured six of the first eight games of the series.
The only connection between the two schools currently on the roster or staffs if U of L offensive line coach Chris Klenakis worked at Iowa State with Houston director of football sports performance Yancy McKnight.
The Cougars have no players from the state of Kentucky on the roster in the first year under head coach Tom Herman, who had previously been the offensive coordinator at Ohio State.
The two schools had also previously been in the C-USA conference together.