The series between Louisville and Virginia has only been three games.
But those three games have been nailbitters with the outcome a combined five points. Virginia leads the series 2-1, including a 23-21 victory last season in Charlottesville, Va.
The fourth game in the series will kickoff at 12:30 p.m. on Saturday at Papa John's Cardinal Stadium.
It will mark the Cavaliers first visit to Louisville since 1988 - the first game in the series - when the Cardinals pulled out a 30-28 victory. In that game, Ron Bell kicked a 39-yard field goal with 10 seconds left to give the Cardinals a victory.
Bell was used as the kicker after Howard Schnellenberger replaced then freshman Klaus Wilmsmeyer, who had missed two extra-point conversions. At the time, Schnellenberger called the victory "one of the greatest of all time" for the Cardinals.
One year later, Jake McInerney kicked a 37-yard field goal as time expired to give the Cavaliers a 16-15 win in Charlottesville. Browning Nagle threw for 194 yards and one TD and Bell had given the Cardinals a 15-13 lead with a 27-yard field goal on their final possession.
It was a field goal last season with 3:41 left by Ian Frey that lifted Virginia to the victory. Louisville fell behind 20-7 but WIll Gardner's TD pass to James Quick with 6:59 left gave the Cardinals a 21-20 lead.
Quick then fumbled a punt when he was bumped into by a teammate, leading to the Frey field goal.