Senior Damion Lee scored his Louisville career-high 24 points and freshman Ray Spalding had his breakout performance - 18 points and 12 rebounds - as the Cardinals used their size and defense blowout previously undefeated North Florida 89-61.
The Cardinals (3-0) won the battle of the boards 53-22 and had 25 second-chance points in the game to knock off previously undefeated North Florida (3-1), which was leading the country at 99 points a game.
The Ospreys did make 11 three-point field goals but nine in the first half. The Cardinals sped up the tempo in the second half and left the Ospresy in their dust. Louisville hit 21 of 34 from the field in the second 20 minutes.
Spalding had his first career double-double and also finished with four steals and two blocks, while senior Trey Lewis had 15 points for the Cardinals. Chinanu Onuaku added six points, nine rebounds, five assists and five steals.
Dallas Moore's 21 points led North Florida (3-1), which hit 11 of 23 from three-point range. The Ospreys were just 7 of 25 from the field in the second half.
It's the first time in school history that Louisville has started the season with three consecutive 28-point or more blowouts.