It wasn't pretty.
"It was disgusting," Louisville women's coach Jeff Walz said of his team's performance.
The Cardinals hit just 36.4 percent from the floor, were outrebounded 36-27 and seemingly couldn't stop Kentucky on defense as the Wildcats rolled to a 72-54 victory and a fifth straight win in the series.
"We have a long way to go," Walz said. "I'm really disappointed."
Briahanna Jackson led the way for U of L with 18 points and a team-high seven rebounds, while Myisha Hines-Allen had 16 points for the Cardinals (3-5), who had their two-game winning streak snapped.
Louisville fell behind early after Kentucky opened the game with three-consecutive baskets for a 7-0 lead and the Cardinals never led. After the initial surge by UK, the Cardinals never pulled closer than four points.
Twice the Cardinals had a chance to cut the lead to 10 points - after it had grown to as much as 17 - but one time Jackson missed a layup and the next time the Cardinals turned it over.
Louisville returns to action on Sunday at home against IUPUI at 2 o'clock.
“You have 2 choices," Walz said he told his team. "Crawl in a hole and feel sorry for yourself and get your ass beat on Sunday or come back and fight. I’m going to come back to practice tomorrow at 2 and fight. Now, I’m not sure if they’re all going to join me. You can come and watch at 2 if you want because it’s going to be fun."