The only teams the University of Louisville basketball program has played more than Western Kentucky University is Cincinnati and Memphis. But the Cardinals have not led in the series since the 1930s.
On Saturday, U of L will get a chance to take the series lead.
Louisville will host WKU in a Bluegrass Battle at noon on Saturday in the KFC Yum Center. The Toppers won seven of the first 11 meetings between the two schools but have dropped six in a row.
"It's a great series," said U of L assistant coach Ralph Willard, who was the head coach at WKU from 1990-94.
The series is tied at 39 and this game is the 11th matchup in the past 22 years.
Louisville lost the first game when the series was renewed in 2008 - the Cardinals were ranked No. 3 at the time - but have won them all since including a 76-67 meeting last season in Bowling Green.
There was some tension and pushing and shoving in last year's game but Willard said that won't "be an issue."
Louisville is 8-1 and leads the nation in average margin of victory at 31.3 points per game, while the Toppers (6-4) have won two in a row and are avaraging 79.3 points a game.
"Every team we've played recently has had a major weakness," Willard said. "But Western has tremendous shooting, good inside play and they shoot free throws well."
Willard went on to say WKU "present a lot of different facets that we have to get better at."