University of Louisville sophomore center Chinanu Onuaku turned in one of his best efforts of the season.
Onuaku had 18 points, 10 rebounds, three blocked shots and two steals in 33 minutes as the Cardinals decked Pittsburgh 59-41, holding the Panthers to 44 points under their scoring average for the season.
It was the fourth consecutive double-double for Onuaku.
Damion Lee added 18 points, five rebounds and four steals for the Cardinals, while Quentin Snider had eight points and three assists and Ray Spalding had four points, four rebounds and two blocked shots.
Pitt drops to 14-2 on the season and saw its 10-game winning streak snapped. The Panthers offensive output was the school's fifth lwest since the 1955-54 season.
Louisville led 20-17 at halftime and hit 21 of 51 from the field. The Cardinals held the Panthers to 14 of 49 shooting.