It will be a meeting of old foes on Sunday at the KFC Yum Center.
Louisville and DePaul battled in Conference USA and later in the Big East Conference and now will meet in the second round of the NCAA Tournament with a spot in the Sweet 16 on the line.
It will be the 32nd meeting between the two schools with DePaul leading 16-15.
Even the two coaches are buddies as U of L coach Jeff Walz said he considers 30-year DePaul coach Doug Bruno "a close friend," with Bruno taking a jab at Walz for not being a great drinking buddy.
Bruno said the ninth-year U of L coach has "one flaw."
"He couldn't hang with the rest of the Big East coaches," during at their annual meetings a decade ago. "You can figure out what that means. And please put that in proper context."
Walz said Bruno isn't lying because "not many people can hang with him."
"Listen, he's not talking about all the coaches," Walz said. "He's talking about himself and that's one thing I've learned. You don't want to sit down with Doug. You might not get up."
Now, back to basketball the game should also be something to toast.
Louisville (26-7) averages 72.2 points a game and allowed just 59, while DePaul (26-8) averages 81.4 points a contest and has allowed 64.8 from opponents. The two teams stats are nearly mirror images.
"They showed you what they can do and that wasn't an accident," Walz said of DePaul, who belted James Madison in the opener. "They shoot the ball extremely well, they pass the ball, they are just an outstanding team."
The Cardinals hope the home court will be an advantage. U of L drew 5,800 fans on Friday and Walz hopes to double that on Sunday. Bruno said he has told his team to embrace the atmosphere.
"We're really excited about the opportunity," he said. "It's always to play in the NCAA tournament and in such a great environment. We know it's going to be hostile, but so what? It's going to be fun."
The Blue Demons lead the all-time series 16-15 with the Cardinals and the two teams split in the 2012-13 season.
DePaul scored 70 points in a loss to No. 1 UConn and dropped a 95-90 decision to Notre Dame this season.
"They can score," Walz said. "We're going to have to play defense or else we'll turn our gear in and get ready for individuals (for next season) to start on Tuesday. It's as simple as that."