DePaul's Jessica January scored 18 of her 25 points in the first half as DePaul built a 10-point lead and held on to knock Louisville out of the NCAA Tournament with a 73-72 decision before 7,515 fans at the KFC Yum Center.
Louisville's Briahanna Jackson helped the Cardinals make a the comeback and tied the game with a reverse layup at :15. But Jackson was called for a foul against January - her fifth - with 14.5 seconds left.
January hit a free throw and then Myisha Hines-Allen was called for a charge with 1.7 seconds left.
Louisville ends the season at 26-8. Jackson led the way with 20 points, six rebounds and five assists, while Hines-Allen had 14 points and nine rebounds and Mariya Moore chipped in 14 points and 10 boards.