The University of Louisville football team only has two wins in the series against Florida State.
But one of those was a 26-20 decision in overtime on Sept. 26 of 2002, which marks one of the biggest wins in program history. Henry Miller scored on a 25-yard TD run in overtime in a game that was played in a downpour.
Louisville's only other win was a 40-14 decision in the first meeting between the two schools in 1952.
The Cardinals trail the series 14-2 but will get another chance for a signature win on Saturday when the Seminoles visit Papa John's Cardinal Stadium for a top-10 matchup at noon.
"It's a big opportunity for us," U of L coach Bobby Petrino said. "It's a great opportunity for this football team."
The Cardinals are just 1-5 in Louisville against the Seminoles and lost each of the last two seasons under Petrino - after the move into the ACC - despite leading Florida State at halftime.
A year ago in Tallahasse, Fla., U of L led 7-6 before being outscored 35-14 in the second half. The Cardinals led 21-0 in the second quarter two years ago before the Jameis Winston-led Seminoles won the game 42-31.
Louisville has been shut out five times in the series, while the Seminoles have scored fewer than 14 points just one time in the 16 meetings.