Saturday marks just the third meeting between the two programs, with Clemson winning the prior two meetings by a total of nine points. The Tigers won 20-17 in Louisville last fall en route to the College Football Playoff game. Louisville fell 23-17 at Clemson two seasons ago.
No.3 Louisville enters the game as the slight field goal favorite over No.5 Clemson for a contest that is the feature ABC game of the day and welcomes the popular ESPN College GameDay program to the Tigers campus.
LOCATION: Memorial Stadium, Clemson, SC (81,500)
DATE: Saturday, October 1
KICKOFF: 8:00 p.m.
RADIO: Louisville Sports Properties Network
Play-by-Play: Paul Rogers
Analyst: Alex Kupper
Reporter: Jody Demling
Play-by-Play: Chris Fowler
Analyst: Kirk Herbstreit
Reporter: Sam Ponder, Tom Rinaldi
- The Cardinals are 70-20 as a ranked team and are 8-8 when facing a ranked foe while also being in the top 25.
- A win this weekend would be the 500th in the history of the Louisville program. The Cardinals are 499-450-17 in 98 seasons.
- The Cardinals are looking to go 5-0 for the first time since 2013 and the ninth time in school history. Head coach Bobby Petrino’s teams are trying to go 5-0 for the third time (2006 and 2004).
- Offensively, U of L leads the country in scoring offense (63.5) and total offense (682.0). The Cardinals also check in among the nation's top three in rushing offense, passing offense and passing efficiency.
- The Cardinals defense is 13th in total defense (278.2) and is 11th in sacks per game (3.75).
- Louisville is 3-29-1 on the road against AP Top-25 teams. Head coach Bobby Petrino is an overall record of 3-11 on the road versus ranked opponents, but is 0-4 at Louisville.
- This is just the second matchup of top five teams in the history of Memorial Stadium. The Tigers lost the only such meeting, falling in 2013 to eventual national champion Florida State.
- The Tigers haven't loss since that 2013 gave vs FSU and are enjoying the nation's second longest home win streak at 18.
- Clemson enters the Louisville game having won 18 consecutive regular season games.
- The Clemson defense is one of the most stingiest in 2016, ranking among the nation's top ten in scoring defense (11.0), total defense (218.0), pass defense (125.8), pass efficiency defense (78.44) and tackles for a loss (9.5). The Tigers are 21st in sacks per game (3.25).
- The Tigers have won 10 straight games against ACC teams.
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QB Lamar Jackson : The sophomore accounted for seven more touchdowns last weekend to become the first FBS athlete to enjoy two or more seven touchdown games in the same season during the last ten years. If that doesn't impress you, the Heisman favorite is leading the nation in points responsible for per game with 37.5. That's more than 86 FBS teams are averaging per game.
RB Brandon Radcliff : Senior has produced three consecutive 100-yard outings. In his last three outings, Radcliff has rushed for 405 yards on 43 carries, averaging 9.4 yards per carry.
LB James Hearns : Leading U of L with 4.5 sacks, Hearns also leads the nation with three forced fumbles in four games.
QB Deshawn Watson : Clemson's Heisman Trophy candidate has only lost twice as a starter. The junior has a 22-2 record for a 91.7 percent mark, making him the winningest quarterback in Tiger history.
RB Wayne Gallman : He's currently 10th in school history with 2,552 career rushing yards. He has 13 career 100-yard outings, two shy of tying the school record.
LB Kendall Joseph : A redshirt sophomore who was used sparingly in 2015, is leading the Tigers defense with 34 total tackles. His six tackles for a loss, which includes a sack, also tops the defense. He's also forced a fumble and has an interception.
RELATED: 5 Clemson Players to Watch
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Louisville head coach Bobby Petrino on the Clemson defense:
"Well they’re big and physical. You know they really do a nice job technically. They’re very, very well coached. They have a lot of movement so we’re going to have to block movement with guys that are very big and physical. Probably be the biggest defensive line that we’ve played this year. They play with bigger defensive ends than what we’ve been seeing. A lot of guys went to more speed and quickness, and they went to more size and set the edge by the size that they have.”
Clemson head coach Dabo Sweeny on Louisville offense:
"Offensively they are the best in the country, statistically. It is really kind of freaky when you look at the numbers that they’ve put up. It would be hard to have these kind of numbers in a video game. They are averaging 63 points a game along with 682 yards a game. They are balanced."