It will be the seventh meeting between Louisville and North Carolina State when the teams collide on Saturday at noon.
And while the Cardinals hold a 5-1 record in the series, Louisville coach Bobby Petrino warns the games have been super close.
"We know them well," Petrino said. "They're a very, very good team. A majority of their players are the guys we have been playing against the last two years. We always had really good battles with them and found a way to win in the fourth quarter."
Louisville is 3-0 against the Wolfpack in Louisville, including 30-18 two years ago. The Cardinals also beat N.C. State at home in 1951 (26-2) and 1994 (35-14) in the series.
The lone loss to N.C. State for the Cardinals came on Dec. 27, 2011 in the Belk Bowl when the Wolfpack won 31-24.
In last year's 20-13 win in Raleigh, N.C., the Cardinals managed just 306 yards of total offense and held the Wolfpack to 228 yards. Lamar Jackson had a 68-yard TD run in the first quarter and finished with 121 yards rushing and 103 yards passing.
"They play sound and make you earn it," Petrino said. "We struggled offensively and found some ways to make points."