No. 2 Louisville won its 11th consecutive game with a 9-4 series-sweep victory at Notre Dame on Sunday.
Brendan McKay continued his hot-hitting, going 4-for-4 at the plate, while Colby Fitch added a 3-for-4 outing to fuel the Cardinals to the win.
After dropping behind 4-1 following the opening two innings, the Cardinals began the comeback when Fitch scored on two-out bases loaded walk in the fourth inning. An inning later Fitch drove in McKay on a sacrifice fly to pull Louisville within a run after five innings.
Fitch drove in another two runs in the seventh when he connected for a single to centerfield to plate McKay and Devin Hairston for a 5-4 lead.
The Cardinals put the game out of reach in their half of the ninth when McKay hit his team-leading 15th home run that scored a pair of runs. Two batters later, Fitch hit a solo home run to equal his career-high with four RBI. Josh Stowers drove in the game's final run when he hit a single to center to plate Devin Mann.
Louisville starter Nick Bennett lasted just 1.1 innings after allowing four runs on five hits.
Adam Elliott picked up his second win of the season after tossing two scoreless innings of mid-inning relief. Lincoln Henzman threw a perfect ninth inning, striking out two.
Louisville improved to 42-6 overall and 20-4 in ACC play. The Cardinals enjoy a four game lead in the ACC Atlantic Division race with eight games to play.
Up next is a Tuesday night meeting against rival Vanderbilt at Jim Patterson Stadium.