Aided by a leadoff walk and a hit batsman before a pair of back-to-back doubles, host Indiana scored four runs in the second innings to snap No. 2 Louisville's nation-leading 15-game winning streak with a 4-3 victory at Bart Kaufman Field in Bloomington, Ind., on Tuesday evening.
Playing in front of a season-high and vocal crowd of 3,077, the Cardinals latest attempt in a come-from-behind victory came up short.
Josh Stowers hit a solo home run - a line drive shot to left field and his fourth of the season - to put Louisville on the scoreboard.
Sparked by a leadoff triple from Colin Lyman, the Cardinals scored a pair in the fifth inning. After Tyler Fitzgerald drew a one-out walk, Logan Taylor drove a double to right field to score both.
Louisville batters struck out 11 times in the loss, a factor that disappointed the team's skipper.
"Losing is never fun, but it was the approach," U of L head coach Dan McDonnell said afterward. "To give up four runs in one inning and lose is really frustrating. The 11 strikeouts is really gnawing at me. No disrespect to their pitchers, I just didn't like the approach we were in and and didn't like the at-bats that we had."
Junior Rabon Martin picked up the loss after allowing four runs on three hits in just two innings of work.
Louisville fell to 46-7 overall.
Up next for the Cardinals is a regular season ending series against ACC Atlantic Division rival Florida State, who is still working to cement its chances of a post-season bid.
"We've got to have a good practice," McDonnell said. "We're getting to play a really good team in Florida State. They got off to a slow start, but obviously they're super-talented and this is the time of year to play well. Like I always tell our kids, everybody is playing for something this time of year. Don't think what you are playing for is bigger, because everyone is playing for something, especially if you're an NCAA-type team. We've just got to come out and play better this weekend."
The series against the Seminoles begins Thursday evening at Jim Patterson Stadium and will continue through Saturday.