Dean, a junior guard, was one point shy of his career high, set last season against VMI. He had 10 of Louisville's 13 points when the Cardinals (3-1) broke the game open midway through the second half.
Louisville's earlier wins were over Division II teams - BYU-Hawaii last week and Chaminade in the consolation bracket of the Maui Invitational. The Cardinals lost 76-71 to Iowa in the opening round of the eight-team tournament sponsored by EA Sports.
Dean was 4-for-9 from 3-point range, including two in a run that gave the Cardinals a 68-56 lead with 6:13 left. He later came up with two big rebounds when teammates missed the front end of 1-and-1s in the final minute. He went 6-for-6 from the free throw line, all in the final 1:16.
Francisco Garcia had 16 points and Ellis Myles added eight points and 13 rebounds for Louisville, which shot 49.1 percent for the game, including 11-for-20 from 3-point range. The Cardinals made six 3s in an 8-minute stretch of the second half when they pulled away.
Little, a senior forward, was 6-for-6 from the field in the first half as Louisville took a 36-34 lead. He finished 9-for-11 and had six rebounds. His career high was 18 points against Florida as a sophomore.
Matt Haryasz had 18 points and eight rebounds for Stanford, which shot 51 percent in the first half but couldn't stay with Louisville, falling to 38.2 in the second half (13-for-34). The Cardinal were 3-for-10 from 3-point range for the game.
This was the first meeting between the schools.