Francisco Garcia added 12 points and Ellis Myles had 11 points and 10 rebounds for Louisville, which shot 43.2 percent from the field (29-of-67) but was only 18-of-33 from the free throw line. The Cardinals turned the ball over 22 times but forced North Carolina A&T into 24 turnovers and outrebounded the Aggies 58-40.
North Carolina A&T shot 28.1 percent for the game (20-of-71), including going 3-of-18 from 3-point range.
The Cardinals (6-1) broke from a 12-point halftime lead with a 12-5 run that put them up 52-33 with 14 minutes to play.
Sean Booker's 3-point jumper with 9:16 to play got the Aggies (1-8) within 62-45, but a 9-2 run by Louisville pushed the lead to 70-47 with 7:45 to play. Lorenzo Wade had two 3-pointers and O'Bannon added a layup in the spurt.
Booker, a Louisville native, led the Aggies with 19 points while Steven Koger had 13.
North Carolina A&T, coached by former Louisville assistant coach Jerry Eaves, who played on the 1980 NCAA championship team, led 4-2 but the Cardinals outscored the Aggies 17-2 to go up 19-6 with 12:44 left in the first half. Louisville was 6-of-8 from the field during the run while the Aggies were 1-of-7.
O'Bannon had five points and Palacios had four during the run.
The Aggies outscored the Cardinals 11-2 to get with 23-19. But Louisville went on its own 11-2 run to take a 37-23 lead. Brad Gianiny had five points and Myles converted a three-point play during the stretch.