The Cardinals, who had six players score in double figures, were led by junior forward Francisco Garcia. Garcia had 21 points, 4 rebounds and 3 assists.
The game's outcome was never in doubt as Louisville, winners of six straight coming into the game, quickly established control and pulled away from the Green Wave. Despite shooting less than 40-percent in the first half, the Cardinals led 50-29 at the break.
The second half was much the same, as Louisville coach Rick Pitino went to his bench often as his team extended its lead.
The Cardinals reserves, led by 6-6 freshman forward Lorrenzo Wade's 14 points, contributed 31 points off the bench. Freshman Terrance Farley had 5 points, 3 rebounds and one blocked shot, while 6-8 Otis George contributed 4 points and 5 boards.
6-4 Larry O'Bannon, who scored a career-high 30 points Wednesday night against Marquette, finished with 12, while junior guard Taquan Dean pitched in 19 points, 5 rebounds and 5 assists. Juan Palacios and Ellis Myles both finished with double-doubles, posting 11 points and 10 rebounds, respectively.
David Stith was the only Tulane player to finish with double figures, scoring 19 points. The Green Wave made just 16-47 shots on the night for a meager 34%.
With Charlotte falling in overtime to East Carolina Saturday afternoon, Louisville and Cincinnati sit alone in first place in the Conference USA standings.
The Cardinals host the Bearcats Wednesday night at Freedom Hall for sole possession of first place in the league standings.