``I'm calm now,'' said Calipari, who turns 46 on Thursday. ``But when I get near the plane, I'm going to do some back-flips up the steps. I'm so happy.''
Rodney Carney added 24 points and Anthony Rice had 15 -- all in the second half -- for the Tigers (14-10, 7-3 Conference USA), who beat a Top 25 team on the road for the first time in five tries this season and snapped Louisville's nine-game winning streak.
``We played hard, we scrambled and we played hard on defense,'' Calipari said. ``But it was our day.''
Calipari has a 300-120 record in 13 seasons at Massachusetts and Memphis.
A frustrated Pitino kept his players away from the media afterward.
``Our locker room is closed,'' he said. ``I don't think they are worthy of speaking to you.''
Louisville was leading the nation in margin of victory coming into the game (+23), but Pitino has been saying for weeks that the Cardinals have plenty of improvements to make.
The Tigers exposed many of their flaws, outrebounding Louisville 41-30 and holding the nation's fourth-best offense to 33 percent shooting (19-of-58), a season low.
``I knew it was coming,'' Pitino said, ``I just didn't think it would be this bad.''
The Cardinals rank second in the nation in field goal percentage defense, but the Tigers' defense took control early, triggering a 16-5 opening run by holding the Cardinals without a point for more than 9 minutes.
Louisville, averaging 85 points per game, missed seven straight shots and committed five turnovers during the drought. At the end of one sloppy possession, Myles threw up just the ninth 3-point attempt of his career, missing it badly.
``The first 10 shots we took were terrible shots,'' Pitino said.
The Tigers, meanwhile, committed only one turnover in the first 12 minutes after coughing up a season-high 26 in a loss to Houston last Saturday.
Much of that was due to Washington, who repeatedly glided through the Cardinals' full-court pressure for layups.
``I was breaking the press, getting in the middle,'' said Washington, who had five assists and five rebounds. ``I was taking it and they just fell.''
Myles made two free throws with 7:47 left in the half to end Louisville's scoreless stretch. He had a layup and zipped an assist to Francisco Garcia to trim Memphis' lead to 16-11.
Carney then hit two 3-pointers during a 10-2 run that muted the capacity crowd. He and Washington scored 28 of the Tigers' 34 first-half points. The Cardinals mustered only 22 first-half points after missing 15 of 20 shots.
Louisville continued to sputter in the second half, missing 10 of its first 13 shots.
Rice hit a 3-pointer with 16:49 left to launch a decisive 16-2 run. Garcia hit a free throw with 11:05 left, but Rice made a 3-pointer to push the lead to 57-31, the Tigers' biggest to that point.
``I was shocked,'' Washington said. ``We got them down and we kept them down.''
Dean hit a 3-pointer with 7 minutes left as Louisville's defense finally started generating turnovers and easy baskets.
A layup by Myles with 5:12 to go trimmed Louisville's deficit to 66-49, but Rice made four free throws over the next minute as the Tigers pushed the lead back over 20.
The victory was a much-needed confidence boost for a team that's dealt with its share of adversity. Last month, guard Jeremy Hunt was briefly suspended after he was charged with assaulting his ex-girlfriend and forward Sean Banks was ruled ineligible because of poor grades.
``It helps us a lot to beat Top 25 team,'' Carney said. ``Not a lot of teams come in here and win.''
Louisville had a 10-game home-court winning streak snapped and matched its worst defeat at Freedom Hall since a 74-57 loss to UAB on Feb. 28, 2001, former coach Denny Crum's final regular-season home game.
Garcia, Louisville's leading scorer, went 1-for-8 and scored seven points.