Head coach Bobby Petrino is 3-0 in season openers as head coach of the Cardinals and is 7-0 in the month of September.
With Brian Brohm's first quarter touchdown run, the Cardinals extended their streak of consecutive game's with a rushing touchdown to 22.
On the game's first drive, sophomore quarterback Brian Brohm, making his first career start, directed the Cardinals on a 13-play, 76-yard drive which ended in a one-yard Brohm run. It was Brohm's third career touchdown run. He added another one in the second quarter on a one-yard run.
Senior wide receiver Joshua Tinch caught a pass in the first quarter to extend his streak to 17 games with a reception.
The Cardinals played just one true freshman in Lamar Alston.
Senior Elvis Dumervil set a new school record for sacks in a game with six, breaking the old mark of five by Mike Flores against Murray State in 1990.
Junior Michael Bush registered his fourth career 100-yard rushing performance gaining 128 yards on a career-high 27 carries. The junior also recorded two second quarter touchdowns.