McGill, a junior who rushed for 419 yards and five touchdowns last season, has been sidelined this season with a torn chest muscle. He had surgery June 19 to repair the torn pectoral muscle sustained while lifting weights.
"From what I gather, Ronnie is going to be allowed to go full-go this week," UNC coach John Bunting said. "If that is the case, I think there is a very good chance that he will be playing on Saturday versus Louisville."
McGill ended spring practice listed as UNC's No. 1 tailback. He averaged 5.3 yards per carry as a sophomore and led the Tar Heels in rushing with 654 yards as a true freshman. In his absence, UNC has struggled running the ball this season, averaging just 87 yards per game for a paltry 2.5 average per carry.