Poe, who rushed for 1,500 yards and 15 touchdowns as senior while leading Freedom High School to an 8-2 record, chose Louisville over Nebraska, Florida, Michigan State, Iowa, West Virginia, Mississippi State and Alabama.
"I committed to Louisville tonight," said Poe, rated a three-star prospect and the 96th best player at his position by Scout.com. "I feel really good about it. I talked to my mom and we both felt it was the best place for me."
Poe visited Nebraska last month, but said he chose the Cardinals for the chance to play running back in Bobby Petrino's offense.
"I think I can adjust to their offense even though it's not what my high school team runs," said Poe. "This is a firm commitment and I'm done with my recruitment. This is a weight off my back and I can just work on school now."
Poe will take the ACT for the first time December 10. He'll make an official visit to Louisville Dec. 16.
The Orlando standout recently was selected Class 6A co-Player of the Year by Florida Athletic Coaches Association District 10 (Orange, Osceola counties).