The senior guard scored 20 points in the win, while sophomore David Padgett led the Cardinals with 24. Fellow starters Juan Palacios, Brandon Jenkins and Andre McGee also reached double-figures, helping Louisville to a 89-86 win over the visiting Irish.
With the Cardinals holding a one-point margin with 4:32 remaining in the first half, McGee drained three consecutive trifectas giving U of L it's largest lead of the game at 38-28. Notre Dame closed the opening frame on a 10-6 to close the gap to 44-38 at the break.
Both teams shot 40% or better beyond the arc during the first half, with Louisville connecting on 61.5% of it's shots from the field.
The hot-shooting disappeared during the second half, but Louisville won the important battle of the boards and limited Notre Dame's second chance opportunities.
After grabbing a four-point lead with just over three minutes left in regulation, Louisville needed the last-second shot by Dean to tie the game.
"We wanted to bring him off the double and they were playing to the outside, and if they played it to the outside, we were going to slip Tello to the three," said Rick Pitino of the play. "I asked him why he didn't do it and he said it I didn't want Tello taking the three, I wanted to take the three."
Juan Palacios drained a three-pointer from the corner of the baseline to give the Cardinals an 83-81 overtime lead. Junior Brandon Jenkins added three points and grabbed three of his career-high nine rebounds during the extra five minutes.
"We played probably one of our best games against Villanova, Cincinnati and now," said Pitino. "We're life and death to win at home with a loss on the road. That just tells you how tough it is. We're playing terrific basketball right now. The competition is so keen. It's unbelievable, I've never seen the Big Eeast like this. It's always been great, but it's never been like this, it's truly unbelievable."
Up next for Louisville is a Monday night road trip at rival Cincinnati.