Making his second career start, Smith contributed an early five points to help the Cardinals build an early 22-8 lead after ten minutes of action.
Sophomore Terrence Williams added 11 points, including another impressive dunk, and 7 rebounds during the first half, with Smith finishing the opening half with 8 points and 6 rebounds.
The Cardinals, which led 38-25 at the break, forced 13 turnovers and out-rebounded Miami 23-14 during the first half of play.
"That was a very good defensive effort by our basketball team tonight," said U of L head coach Rick Pitino. "It's much easier when you shoot well. We did a lot of good things at the defensive end tonight."
Sporting a band-aid over his right eye, Smith fueled a strong second half start, connecting on two three-pointers to help U of L build a 50-29 lead with 14:00 left to play. Freshman Earl Clark also contributed two early second half three-pointers.
Louisville held a 23-point advantage during the second half and cruised to a 82-59 win.
Smith finished with a game-high 22 points and 12 rebounds, with Williams adding 18 points and 10 rebounds. The Cardinals also received 10 points from Earl Clark.
"I thought Jerry and T-Will played great," said Pitino.
The Cardinals will wrap the 2006 portion of their season with three games in four days - all at Freedom Hall- beginning Wednesday, December 27 against Northeastern. U of L will also host San Francisco and UNC-Asheville during the month's final week.