David Padgett scored 20 points on 8-9 shooting and kept Louisville in the game during the first half. The Cardinals struggled offensively before the break, hitting just 9-32 shots in the first half, to take a 26-23 lead over the Dons into the locker room. Padgett hit 5-6 first half shots and scored 14 of Louisville's 26 points.
The second half featured 10 lead changes before Louisville freshman guard Jerry Smith nailed a three-pointer with 7:17 left to give the Cardinals the lead for good at 58-56. Over the game's last seven minutes, Louisville steadily pulled away from San Francisco, who has lost their last seven games, out-scoring the Dons 21-7 to end the game.
Rick Pitino also made a key change to his starting lineup against the Dons, inserting 6-9 freshman Earl Clark for Juan Palacios, along with fellow freshmen Edgar Sosa and the 6-1 Smith. Sosa scored 18 points and dished out 8 assists. Smith scored just six points and Clark was held scoreless.