Palacios could be a bigger factor Saturday on the road against the Blue Demons than he has been recently, while McGee could return to action for the first time since re-injuring his knee against Kentucky.
"Tello is about 90 percent," Louisville coach Rick Pitino said. "And Andre will probably suit up for this game and may even play. It would be nice to have him."
McGee, who had knee surgery earlier this season to repair torn cartilage, returned to practice this week. His status won't be known until tip-off.
"He's just had one practice under his belt and I don't know if he'll be able to play in the game," Pitino said. "We'll make a game time decision."
McGee sounded eager to return to the court.
"I'm feeling good now," McGee said Friday. "I practiced yesterday and my range of motion is good. I wouldn't say I'm 100 percent but I'm close to it. If I do play I'm going to play my hardest. I don't like sitting on the sideline."
Pitino will need all the help he can get against DePaul. His team has struggled on the road the past year, having one just one game away from home since the 2004-05 season.
"DePaul is one of the hotter teams in our league right now," Pitino said. "They've won 10 out of their last 13 games and they're a veteran team. They start two seniors, two juniors and a sophomore. So they are one of the more experienced teams in the conference."
Louisville is coming off a home court loss to Marquette earlier this week. The Cardinals will need to do a good job on the boards and find a way to put the ball in the hole at a better clip than they have been against a stingy DePaul outfit.
"They are very physical, they shoot 47 percent and hold their opponents to 40 percent," Pitino said. "That's outstanding."
While Pitino said Friday that Derrick Caracter was working harder in practice, the 6-9 freshman forward will once again not play for Louisville on the road, according to reports on 84 WHAS. Caracter, who played Monday against DePaul, hasn't played a road game this season for the Cardinals.
"He's working harder," Pitino said. "I always have confidence in people who work hard. I am no longer afraid to put him in the game, even though in the last game he immediately gave up six points. He thinks a 2-3 zone is where you get to relax and take a break."