Louisville (13-6, 3-2) has now won their past two Big East road games and heads into a Big Monday showdown against UConn having won three of their last four games.
Things didn't look good early for the Cardinals in Chicago. Rick Pitino's squad missed 11 of their first 13 shots of the game, falling behind 13-5. But then Palacios came in off the bench to score 10 straight points for Louisville, helping the Cardinals draw even at 26 at the break.
After halftime, Louisville jumped out to a quick 32-26 advantage, a lead they wouldn't relinquish the rest of the way. The Cardinals built as much as a 10 point lead in the second half, 41-31, but the Blue Demons never quit, trimming that lead to just one at 43-42 late in the game.
Though Louisville shot just 37 percent from the floor for the game, the Cards were able to escape using a 2-3 zone that held DePaul to just 35 percent shooting. The Blue Demons didn't help themselves at the free throw, either, making just 50 percent of their 18 attempts.
Terrence Williams scored 11 points and was the only other Cardinal player in double figures. He also had 11 rebounds to lead the Cardinals.
Wilson Chandler led DePaul with 19 points and 10 rebounds. Keith Butler has 11 rebounds for the Blue Demons. Louisville also did a good job on Sammy Meija, holding the DePaul senior to just four points.
Louisville's Derrick Caracter did not make the trip to Chicago. His status will be evaluated by Pitino this week. It's unknown why Caracter missed the game or if he'll play Monday against Connecticut. Tip-off Monday night is scheduled for 7 PM.