Oklahoma State (41-19) advanced by winning the Fayetteville Regional also as a No. 3 seed, claiming OSU's first regional title since 1999. The Cowboys knocked off top-seed Arkansas in Sunday's championship final.
As the regional champion, the Cardinals advanced to the NCAA Super Regional to face Oklahoma State. The winner of that series will advance to the College World Series in Omaha, Nebraska.
Louisville started the Columbia Regional championship game with a bang, scoring eight runs in the bottom of the first to take an 8-0 lead over the Tigers. Louisville's slugger, Dominguez, cleared the bases with a grand slam to put U of L up 5-0. The Cardinals had nine hits and sent 13 batters to plate in the first inning.
Dominguez was at the center of controversy in a 4-3 weekend victory over Missouri when he taunted the Tigers while rounding the bases after hitting the game winning home run to keep the Cardinals alive in the regional tournament.
Missouri cut into Louisville's early lead in the top of the second, scoring 5 runs while knocking out two Cardinals pitchers in the inning. But it would be the last serious challenge the Tigers would mount.
In the bottom of the second, Dominguez doubled off the center field wall and scored on Chris Cates base hit to give Louisville a 9-5 after two innings.
While Missouri couldn't get on the scoreboard in the third or fourth innings, Dominguez again came up big for Louisville in the bottom of the fourth. The Cardinals talented freshman third baseman cranked out a three run home run, his second of the game, to the opposite field to give Louisville a 12-5 cushion.
Louisville's Jorge Castillo hit a three run home run in the bottom of the sixth to put the Cardinals ahead 15-5. Dominguez then reached base on a walk and scored when Pete Rodriguez doubled to give U of L a commanding 16-5 lead after five innings.
Missouri's Aaron Senne homered in the top of the sixth to make it 16-6.
Seven Cardinals were named to the All-Regional team: 1B Daniel Burton, 2B Logan Johnson, 3B Chris Dominguez, SS Chris Cates, CF Boomer Whiting, P Kyle Hollinger and P Gavin Logsdon. Dominguez was named the Columbia Regionals Most Outstanding Player.