Thanks to senior forward Juan Palacios and and sophomore guard Jerry Smith, the Cardinals came away with an impressive 89-75 win over Kentucky.
Palacios, who started in place of suspend forward Earl Clark, scored 17 points, while the 6'1 Smith also tossed in 17 points. Junior forward Terrence Williams scored 15 points.
The Cardinals jumped out to an early lead against the Wildcats but slumped late in the first half as the Wildcats took a 31-30 lead into halftime.
But Louisville used a quick 9-0 run to start the second half to put away the Wildcats.
Louisville might have found their magic formula for success in the second half. After making just 3 of 13 three's in the first 20 minutes, the Cardinals attempted only five three-pointers in the second half - and scored a whoppoing 59 points.
Andre McGee scored 11 points, while Edgar Sosa chipped in 10 points for Louisville. The Cardinals shot 25-53 from the floor (47 percent) for the game.
Ramel Bradley scored a game-high 27 points for Kentucky. Joe Crawford was the only other Wildcat player to score in double figures with 19 points.
The Cardinals held Kentucky to 40 percent shooting overall from the field and just 7 of 22 from three-point range. Louisville also made a living at the free throw line, hitting 33 of 46 free throws.