Edgar Sosa led the way for Louisville with 18 points. Sosa, who might have played his best game of the season, hit 5 of 7 shots from the floor and 5 of 5 free throws.
The Cardinals led from start to finish against No. 16 Marquette. Sosa opened the game with a three pointer to give Louisville a 3-0 lead and the Cards never looked back.
Louisville, which shot 58 percent from the field in the first half, took a 34-22 halftime lead. The Cardinals held the Golden Eagles to just 27 percent shooting before the half.
In the second half, Louisville was in control the whole way, steadily increasing their lead throughout the half. The Cardinals biggest lead came at 2:13 when Edgar Sosa hit a two free throws to make the score 70-47.
Marquette hit a trio of three's in the final moments to make the final margin look more respectable. For the game, Louisville hit 51 percent from the floor. The Cardinals also made 19 of 24 free throws (79 percent).
Though Marquette won the battle on the boards, it was another solid defensive effort for Louisville, which limited the Golden Eagles to 32 percent shooting from the field, forced 12 turnovers and blocked 4 shots.
Marquette guard Dominic James didn't start because of the flu, but did play 18 minutes. He scored 8 points and committed three turnovers.
Wesley Matthews led Marquette with 15 points.
Jerry Smith scored 12 points for the Cardinals, while Earl Clark pitched in 11 points and seven rebounds. Terrence Williams added 8 points, 6 rebounds and 6 assists.
Next for Louisville is a showdown with Georgetown Saturday night at Freedom Hall.