The annual senior showcase game will be played on Saturday, Jan. 24 at Ladd-Peebles Stadium in Mobile, Ala. Kickoff is scheduled for 3 p.m., Central Time, and the NFL Network will have the live broadcast.
Collins, a Baton Rouge native, is a consensus first-team All-SEC selection and was recently voted the Tigers' most valuable player at a team banquet Sunday night.
Neighbors, playing in his redshirt senior season, is a former walkon that became a two-year starter at fullback for LSU. His role grew even more in 2014 with J.C. Copeland gone.
The Senior Bowl is expected to feature 86 of the top seniors from around the country.
Counting Collins and Neighbors, LSU has now had a total of 110 players invited to play in the Senior Bowl.
Four more Tiger seniors on top of Collins and Neighbors will play an additional game with an LSU helmet on following the bowl game.
Running backs Kenny Hilliard and Terrence Magee (pictured above) will suit up in the 90th annual East-West Shrine Bowl, as will defensive end Jermauria Rasco and safety Ronald Martin.
The four Class of 2011 members will travel to St. Petersburg, Fla., to play at Tropicana Field. The game is on Jan. 17 and will kick off at 3 p.m. on the NFL Network.
All six seniors - with the possible exception of Hilliard, dealing with a shoulder injury - will be available for LSU in the 2014 Music City Bowl when the Tigers take on Notre Dame Dec. 27 in Nashville.