Grossman, who completed 22 of 33 passes just one interception, had three scoring passes in the first quarter, allowing the Gators to build a 21-3 lead. He went on to eclipse Danny Wuerffel's record of 462 passing yards set in 1996.
"If Rex can throw the ball around like this, it's going to be hard for teams to stop us," said Florida coach Steve Spurrier.
LSU scored its first touchdown of the game in the second quarter on a two-yard run from LaBrandon Toefield. John Corbello missed the extra point, leaving the score at 21-9 with 12:58 to go before halftime. Corbello made a 44-yard field goal in the first quarter but missed on both PAT opportunities.
Grossman responded on the next Florida possession with a 6-play, 48-yard drive that culminated with a 7-yard touchdown pass to Jabar Gaffney. It was the second scoring play of the game for Gaffney, who was on the end of a 63-yard TD pass from Grossman in the first quarter. Gaffney finished with 5 catches for 164 yards, while Reche Caldwell had six receptions, 160 yards and one touchdown.
The next drive would be the last for LSU quarterback Rohan Davey, who was forced from the game after taking a helmet to the knee. The injury was diagnosed as a hyperextension and leaves Davey questionable for next week's game against Kentucky. Redshirt freshman Matt Mauck took Davey's place and ended the night 11-for-22 with two interceptions.
With the score 37-9, Florida back-up quarterback Brock Berlin led the final scoring drive for the Gators, hitting Kelvin Kight with a eight-yard touchdown pass.
Mauck completed his first scoring drive as the Tigers' quarterback, covering 74 yards in five plays. Domanick Davis provided the touchdown on a 1-yard run with 42 seconds left in the game.
As to be expected, Florida dominated in virtually every statistical category. The Gators amassed 632 yards to LSU's 423, and gained an average of 9.4 yards per play.
"They're as good an offensive football team as I've seen in college football," said LSU head coach Nick Saban.
Despite the loss, LSU wide receiver Josh Reed recorded his 11th career 100-yard game, taking in six passes for 123 yards. Wendell Davis holds the school record in the category with 13 100-yard receiving performances. Reed also moved from ninth to a sixth place tie on the all-time LSU receiving yardage list. He and Abram Booty have 1,768 yards.
- Recruits in attendance at the LSU-Florida game included: Berwick RB/LB Brian Henderson; Muscle Shoals, Ala. ATH Jason Allen; Evangel QB John David Booty; Batesville, Miss. LB Chris Herring.