Ivan Naccarata hit two, 3-run home runs and collected seven RBIs to lead the LSU attack. Blake Gill went 4-for-5 with a double and three singles and Nate Bumstead improved to 4-0 pitching 7 1/3 innings, in which he allowed just two earned runs on 10 hits with a pair of K's.
Naccarata's seven RBIs was the most by an LSU player since Bryan Moore had seven in a 15-7 win over Arizona State on March 3, 2001.
The Tigers (21-4, 4-2 in SEC) have not lost a weekend this season winning all seven. It was LSU's first win in a series over Mississippi State in Alex Box Stadium since the Tigers took 2-of-3 in 1998.
The Bulldogs (14-8, 2-4) took an early lead on a Brad Jones home run in the second inning. However, LSU scored a touchdown in the third when the Tigers exploded for seven runs, fueled by the first of Naccarata's two, 3-run round trippers.
LSU scored a single run in the fifth and added 3-spots in the seventh and eighth innings. Naccarata hit his second round tripper in the seventh.
For the second day in a row LSU had a pitcher last until the eighth inning. Clay Dirks went eight complete on Saturday while Bumstead went 7 1/3 Sunday before giving way to Lane Mestepey who pitched the final 1 2/3 innings.
On the weekend, LSU hit six home runs, but committed six errors. In all, the Tigers scored 26 runs and collected 35 hits.
LSU returns to action Tuesday when they travel to New Orleans for a 6:30 date with UNO at Privateer Park.