The regional crown marked the eighth in program history and the second in three years for the Tigers.
"This was probably our best regional performance in school history," said LSU head coach D-D Breaux. "We kicked it up a notch. We practiced harder than I thought we would have to going into this meet, but I believe it paid off."
LSU used four event scores of 49.275 or better, including a school record 49.525 on the vault, to finish with a meet-best 197.500. Arizona State placed second with a 196.500 and will be joining the Tigers at the NCAA Championships in Los Angeles, Calif., April 15-17.
Burkholder paced the LSU squad winning the all-around (39.675) and floor (9.950) titles outright, while sharing top honors on the vault (9.950) and bars (9.900).
Freshman Nicki Butler and junior Annie Gagnon joined Burkholder in the winner's circle. Butler also notched a 9.950 on the vault, while Gagnon tied with Burkholder on the bars with a 9.900.
Other top performances included Gagnon's career-high tying 9.900 on the beam that tied her for second on the event and freshman Kelly Phelan's 9.875 on the floor that placed her third overall.