The victory for LSU (9-1, 6-1 SEC) was by the largest margin by an Ole Miss opponent in Oxford since a 47-0 defeat at the hands of Kentucky in 1949.
The Rebels fell to 3-7 overall and 1-6 in SEC play.
LSU runningbacks Joseph Addai ran for 70 yards on 14 carries, while Justin Vincent also carried 14 times for 54 yards. Each scored a touchdown on the ground.
Quarterback JaMarcus Russell finished 13 of 22 for 142 yards and two touchdowns. His backup, Matt Flynn, entered in the fourth quarter and tossed a 55-yard touchdown pass. He finished 2 of 4 for 61 yards.
LSU gave up only seven yards rushing on 22 Rebels attempts. The Tigers out-gained Ole Miss, 381-175 and scored on all four red zone appearances.
Ole Miss backup quarterback Michael Spurlock was 11 of 23 for 119 yards and a touchdown. Four Ole Miss runners each had less than 10 yards rushing.
Ole Miss won the toss and deferred to the second half, giving the Tigers the ball to start the game.
The Tigers' offense stalled after a 19-yard completion from Russell to Bowe, allowing punter Chris Jackson to pin the Rebels at their 14. An illegal block by the Rebels foiled the first drive.
After LSU again watched its drive end in Ole Miss territory, Jackson's punt put the Tigers in positive field position. The Rebels took over at the 11 and were penalized five yards for a false start. Consecutive rushes for lost yardage give the Rebels a third-and-20 from the 1.
Much like the way the 2003 LSU-Ole Miss game ended, Flatt was stepped upon by his pulling guard, fumbled in the endzone and recovered for an LSU team safety.
LSU led 2-0 with 5:27 to play in the first quarter.
Skyler Green returned the Ole Miss punted free kick 24 yards to the Ole Miss 48, but a holding penalty on the first play of the drive stopped the Tigers in their tracks.
Another fine punt by Jackson pushed the Rebels to their 17-yard line and forced a three-and-out.
Green returned the Ole Miss punt 16 yards to the Ole Miss 47, where Russell connected with Craig Davis for a 32-yard reception. Four consecutive rushes by Justin Vincent advanced the Tigers to the Rebel 3-yard line when the first quarter ended.
Including the safety, the Tigers have outscored opponents 70-10 and have allowed only one touchdown (Mississippi State) in the first quarter this season.
On the second play of the quarter, Davis earned his first touchdown reception of the season on a perfect pass from Russell over the top of the Ole Miss defense.
LSU led 9-0 after the four-play, 47-yard drive that took 2:59.
Ole Miss again went three-and-out, and gave the Tigers another start inside Rebel territory at the 45. Nine plays later, Joseph Addai ran untouched over the left side of the LSU line for a 1-yard touchdown. Addai's eighth rushing touchdown of the season and 17th of his career gave LSU a 16-0 lead with 9:42 to play in the half.
A third-straight drive without a first down allowed LSU to start its fourth-straight drive in Ole Miss territory at the 44. However, on the second play of the drive, Davis bobbled a long pass by Russell at the goal line and Rebel safety Charles Clark intercepted the ball in the endzone for a touchback.
Ole Miss again went without a first down and LSU took over at their 46-yard line. With Vincent running through and around the Rebels defensive line, the Tigers looked to be headed for another score before the half. However, on his fourth run in a row, Vincent had the ball stripped by Ole Miss' Corvelli Haynes. Jayme Mitchell picked up the ball for Ole Miss and returned to the Rebels 36-yard line.
However, Ole Miss' longest drive of the game ended at the LSU 40-yard line on Jessie Daniels' first interception of the season at the LSU 18.
Ole Miss' did not get into LSU territory until this final drive of half with 1:20 to play.
Prior to that drive, the Rebels did not get past their 28-yard line, which came on their second offensive play of the game.
LSU led 16-0 at the half.
In the half, the Tigers out-gained Ole Miss 178-36 and held the Rebels to minus-13 yards rushing.
LSU wasted no time in the second half, driving 68 yards and scoring on its first possession with a 20-yard reception by Early Doucet from Russell. The Tigers led 23-0 with 8:36 left in the third quarter.
A season-long 48-yard field goal by Jackson extended the lead to 26-0 at the 4:04 mark of the third quarter.
The scoring continued with a fourth-and-goal touchdown 1-yard run by Vincent and a 55-yard pass from backup quarterback Matt Flynn to Bennie Brazell with 11:44 to play in the game.
LSU led 40-0.
The reception was Brazell's second career touchdown and, more remarkably, Flynn's fourth touchdown pass in 12 pass attempts this season.
Ole Miss scored their lone touchdown with 2:28 to play in the game, a 7-yard reception from Michael Spurlock to Taye Biddle
The Tigers return to action on Friday, Nov. 25, when they complete the regular season against Arkansas (4-6, 2-5 SEC) at 1:30 p.m. on CBS.
Tigers rout Rebels
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