LSU (22-2, 10-1 SEC) saw its 24-game Southeastern Conference winning streak snapped with the loss.
Florida (19-6, 7-5 SEC) trailed 61-53 with just under six minutes remaining in regulation, finished the game on a 12-2 run to tie the score. Lowe, who finished the game with 17 points, connected on a baseline jumper with just under a minute to play for the tie.
The Lady Tigers used an 11-2 run of its own to take a 58-46 lead, it largest of the game, with 9:08 left, but the Gators would not go away.
"I give a lot of credit to Florida," LSU head coach Pokey Chatman. "Florida forced us into 22 turnovers and they established an offensive rhythm early in the game."
Florida's first lead did not come until the 1:56 mark of the overtime period and a three-pointer by Dalila Eshe. Eshe scored the first eight points of overtime for UF and finished the game with 22.
Seimone Augustus led LSU with a career-high 35 points and seven rebounds. Sylvia Fowles added 23 points and 16 rebounds.
LSU shot 51.7 percent from the floor in the game, but were only able to convert 14 of 26 free throw attempts.
"Despite our shooting from the floor, we were never able to really get into an offensive rhythm and I credit Florida's defense," Chatman added."
The Lady Tigers committed a season-high 22 turnovers that led to 19 Florida points.
Sha Brooks led the Gators with a career-high 25 points, including four three-pointers.
As a team, Florida connected on 9-16 three-pointers and hit 18 of 24 free throws, including five of six in overtime.
LSU, which still sits on-top of the SEC standings, hosts Arkansas on Sunday at 2 p.m. CST in the Pete Maravich Assembly Center.
- Seimone Augustus recorded her 86th straight double figure scoring game with a career-high 35 points.
- Augustus' 35 points marks the 63rd time in her career to reach at least 20 points. She has done so 17 times this season. Her 35 also gives her at least 30 points for the fourth time in her career and third time this season.
- Sylvia Fowles collected her 16th double double of the season and 28th of her career with 23 points and 16 rebounds.
- LSU's played in 25th overtime in the program's history, falling to 15-10.
Lady Tigers run ends at UF
Tiger Blitz Top Stories
Live Updates: LSU seeks redemption vs. OSUFollow Tiger Blitz' Randy Rosetta for the latest from Omaha as LSU looks to get redemption against Oregon State in the College World Series.
Tiger Blitz11:42 AM
LSU offers Louisiana running back A.J. CarterLSU extended an offer on Friday to 2018 Many (La.) running back and UCLA commit A.J. Carter, who earned his offer after his camp performance.
Tiger Blitz11:15 AM
CWS ON DECK | LSU vs. Oregon StateIn search of a spot in the championship round, the Tigers take another shot at the No. 1-ranked Beavers in the semifinals
Tiger Blitz6:08 AM
LSU Elite Camp Day 2 Live UpdatesIt's Day 2 of LSU's Elite Football Camp. After Day 1 yielded a commitment and plenty of notes, Day 2 is expected to be even bigger. Follow along for the latest.
Tiger Blitz5:37 AM