The Tigers are coming off a home loss to Georgia, marking the Bayou Bengals second conference loss in three weeks.
In both losses, the Tiger defense allowed 50-plus points for a combined 103 points.
The Tigers, who have yet to lose back-to-back games under the Les Miles era, look to rebound against the Green Wave in much of the same fashion they did against South Carolina following the loss in Gainesville.
The Tigers have won 16 straight games against the Green Wave, the last loss coming on Nov. 27, 1982 in a 31-28 contest.
The Tigers lead the all time series 67-22-7.
Offensively, the Tigers look to get back on track behind the running game of Charles Scott, who was fast out of the starting gates as one of the conference’s top backs.
He carried the ball 21 times for 144 yards and a pair of touchdowns against the Bulldogs last week. On the season, Scott has moved his totals to 775 yards and ten touchdowns on 120 carries.
Starting quarterback Jarrett Lee (98-1869-9-1,328 10 TDs) continues to go through the learning curve of playing college football in the Southeastern Conference, going 14-of-28 for 287 yards against Georgia.
While Lee threw for three touchdowns, the Texas-native also threw three interceptions, two which were returned by Georgia linebacker Darryl Gamble for touchdowns.
With back up quarterback Andrew Hatch's status doubtful for the contest against the Green Wave, Destrehan-native Jordan Jefferson is expected to get some looks behind center for the Tigers, who continue to try to find an offensive identity.
Jefferson, who is coming back from a shoulder injury, was incomplete on his only pass attempt of the season and has carried the ball twice for 16 yards.
Brandon LaFell, coming off of a two touchdown performance against the Bulldogs, continues to lead the Tigers at the wide out spot. LaFell has pulled in 36 catches for 524 yards and five touchdowns on the season.
Senior Demetrius Byrd trails LaFell in production with 23 receptions for 353 yards and three touchdowns.
On defense, Harry Coleman continues to lead the Tigers in tackles with 41 on the season, including 25 solos, as well as a forced fumble and fumble recovery.
For the Green Wave, the biggest drawback heading into the weekend comes with the loss of running back Andre Anderson.
Anderson, who ranks eighth in the nation with 864 rushing yards and has run for seven touchdowns, left last weekend's game early favoring his right shoulder. An MRI revealed both a fracture and dislocation, which required season-ending surgery.
With 25 receptions for 202 yards and one TD, Anderson was also Tulane's second leading receiver.
Green Wave coach Bob Toledo says freshman Nate Austin will replace Anderson.
Sophomore Kevin Moore has handled the Green Wave's duties from under center this season, completing on 128-of-217 passes for 1,476 yards, seven touchdowns and eight interceptions.
While Moore has remained the starter all season, he was benched last week after Rice took a 35-0 halftime lead. Redshirt freshman Joe Kemp stepped in and played well in relief, completing on 14-of-20 for 201 yards and two touchdowns.
Jeremy Williams, who has pulled in 27 receptions for 437 yards and five touchdowns, remains sidelined for the third straight week after suffering a broken hand in the Green Wave's game against Army.
LSU heads into the game riding a 21-3 overall mark under Les Miles in Tiger Stadium.