A win over the Razorbacks will give the Tigers at least eight wins for a school-record ninth straight season, a streak that dates back to the 2000 season.
The Tigers, who dropped out of the polls on Sunday after the loss to Ole Miss, will play a game as an unranked team for the first time since the Cotton Bowl in January of 2003.
LSU and Arkansas meet for the 54th time with the Tigers holding a 33-18-2 advantage in the series.
LSU is 8-5 in Little Rock, including a 1-0 record under Les Miles.
Arkansas, under the direction of first-year coach Bobby Petrino, is 4-7 overall and 1-6 in conference action.
The Hogs lost their bid to become bowl eligible last week in a 31-28 setback to Mississippi State.
Friday's game will also serve as the battle for "The Boot" as the Tigers and Hogs will play for the trophy for the 13th straight season. Arkansas is currently in possession of the Boot after winning in Tiger Stadium a year ago by a 50-48 count in triple overtime.
LSU goes into the Arkansas game having won 699 games during its 115 years of playing football, leaving the school just one victory shy of reaching the 700-win mark.
The Tigers go into the Arkansas game averaging 30.4 points and 377.9 yards per game. The Tigers are No. 4 in the league in rushing (167.8 ypg) and No. 6 in passing (210.1 ypg).
LSU's Jordan Jefferson should become the first true freshman to start at quarterback for the Tigers since 1995 when Herb Tyler took over as the starting quarterback late in the year.
Jefferson has completed 11-of-27 through the air for 134 yards with one touchdown and one interception.
Jarrett Lee could see action but he’s still battling an ankle injury. He has completed 143-of-269 passes for 1,873 yards with 14 touchdowns and 16 interceptions.
Charles Scott became the 12th 1,000-yard rusher in school history. He goes into the Arkansas game with 1,081 yards and 14 scores. Scott continues to rank among the best in the SEC in rushing as he's No. 4 in the league with 98.3 yards per game.
Brandon LaFell currently leads the SEC in receptions per game (5.4) and he's No. 2 in receiving yards per game (77.6). He has 59 receptions for 854 yards and 7 touchdowns on the year.
Richard Dickson ranks third on the team with 25 catches for 255 yards and three scores. He now has 63 receptions in his career, which ranks fifth in school history for a tight end. Mitch Andrews holds the LSU career mark with 87.
Defensively, LSU is allowing 25.5 points and 320.0 yards per game.
Place kicker Colt David, who owns the LSU career scoring mark, ranks No. 5 in SEC history in points with 349 for his career.
LSU coach Les Miles is now 22-9 in SEC regular season games after the loss to Ole Miss.
Miles is 9-0 during his career with the Tigers in games following a loss. In addition, LSU hasn't lost back-to-back games since the 2002 season.
Arkansas has played a total of 16 true freshmen in the 2008 season.
Offensively, Arkansas averages 21.1 points and 370.8 yards a game. The Hogs average 113.1 yards on the ground and 257.7 through the air.
Michael Smith is the SEC’s No. 2 rusher as the junior tailback has carried the ball 207 times for 1,027 yards and eight touchdowns.
Nathan Dick, who took over the starting job last week against the Bulldogs in place of older brother Casey Dick, completed 25-of-43 through the air for 333 yards with three touchdowns and an interception in his first collegiate start.
Picks have been a problem for Arkansas this year as Casey has thrown 14 interceptions against 11 touchdowns. Casey has passed for 2,389 yards and completed 187-of-328 passes.
Lucas Miller emerged last week as another weapon for the Hogs and had a career high 10 catches for 201 yards and a touchdown. That was only the second time in school history that a player had more than 200 yards receiving in a game and it pushed his season totals to 27 catches for 443 yards and a pair of scores.
The Razorbacks have allowed 40 sacks on the year which is the most in all of the Football Bowl Subdivision ranks out of 119 schools.
Arkansas is 12th in the conference at scoring defense at 31.3 points a game, and the Hawgs are dead last at giving up 381.6 yards a contest.
Arkansas is in the cellar with rushing defense at 171.6 yards a game allowed, but the Hawgs fare better against the pass, checking in at 210 yards a game.
Malcolm Sheppard is third on the team with 60 stops and he leads the team with 12 quarterback hurries. His four forced fumbles and 11 tackles for loss also leads the defense.
Kickoff for the Friday contest is scheduled for 1:30 p.m. from War Memorial Stadium.