The Lady Tigers (24-3, 11-3 SEC) finished second in the Southeastern Conference and head into the SEC Tournament as the No. 2 seed. Vanderbilt (19-8, 9-5 SEC) will be the sixth-seed in next week's tournament.
VU jumped out to an early 20-12 lead in the first half before LSU used a 12-2 run and take a 24-22 lead with just over three minutes remaining in the first half. Vanderbilt then took a 30-28 lead into the locker room at the break.
The Commodores then jumped out early in the second half and used a 9-2 run to pull away for good. LSU was able to get within seven with 6:20 to play after a lay-up by Doneeka Hodges, but the Commodores retook a double figure lead.
Hodges led the Lady Tigers with 14 points, all in the second half on four three-pointers. Temeka Johnson, Seimone Augustus and Aiysha Smith each added 12 points, while Smith grabbed a team-high 10 rebounds.
LSU committed 21 turnovers and Vanderbilt scored 14 points off of those and outrebounded the Lady Tigers 38-36. VU shot 41.4 percent from the floor and hit 21 of 24 free throws and LSU hit 41 percent from the floor and just four of seven from the line.
LSU will travel to Little Rock, Ark., for the Southeastern Conference Tournament and play Friday at 2:30 p.m. CST as the No. 2 seed in Alltel Arena. The Lady Tigers will face the winner of the No. 6 seed Arkansas vs. No. 10 seed Alabama.