LSU trailed 60-56 after Justin Reed's jumper with 8:04 remaining before the Tiger defense held the Rebels without a field goal for just over seven minutes.
Ronald Dupree and Jaime Lloreda each had five points in the span as the Tigers scored 15 straight to take a 71-60 lead with 2:15 to go. David Sanders ended the drought with a three-pointer with 43 seconds remaining.
Torris Bright scored 22 points, six in the final three minutes, and Dupree chipped in 18 as LSU continued its late-season tear. Lloreda finished with 13 points and Antonio Hudson added 10 off the bench.
The Tigers (18-9, 7-8) have now won four straight games and six of their last eight. Last season, LSU had a similar late push, winning six of their last nine contests to reach the NIT.
After starting the Southeastern Conference season 3-1, including a win over LSU, Ole Miss (12-13, 3-11) has dropped 10 straight games. This loss came in the final home game for five Rebel seniors.
Dupree, who scored in double-figures for the 26th straight game, hit 8-of-11 field goals attempts to lead the Tigers to a 54.5 percent (24-of-44) shooting night.
Led by Bright's 7-of-10 performance, LSU had a huge advantage at the free throw line by hitting 23-of-36 compared to 13-of-18 for Ole Miss.
Ole Miss jumped out to an early 12-3 on David Sanders three-pointer with 14:03 left in the first half. Sanders had four points and Emmanuel Wade had five in the span.
The lead grew to 10, 18-8, at the 12:40 mark on Wade's third three-pointer of the game. Wade finished the game with a team-high 18 points, 11 in the first eight minutes. Sanders, Reed and Derrick Allen each reached double-figures with 13
LSU methodically climbed back into the game and Xavier Whipple knocked down a three with 51 seconds left to send the Tigers into the locker room trailing, 35-32.
Lloreda, who scored 13 points, gave LSU its first lead, 48-47, on a dunk with 12:41 left. However, Ole Miss answered to go ahead, 58-54, after Aaron Harper knocked down a three with 9:38 to go.
Tigers spoil Ole Miss senior night
Tiger Blitz Top Stories
LSU Football Defensive Bye Week GradebookLSU's defense has been the Tigers' rock this season under Dave Aranda, but did their grades all come out perfect in Tiger Blitz' Bye Week Gradebook?
Tiger Blitz9:08 AM
Five Questions LSU must answer stillThe Tigers certainly have already answered a lot of questions this team had following the Auburn loss, but there’s still some questions that the Tigers have to answer to achieve…
Tiger Blitz1:00 AM
LSU Football Offensive Bye Week GradebookTiger Blitz hands out grades for the first half of the season for the LSU Tigers on offense as they enjoy their bye week.
Tiger BlitzYesterday at 6:45 AM
LSU OL commit honored to be a TigerTiger Blitz was in DeSoto, Tex. to check in on 2017 LSU offensive line commit Ed Ingram and to get his thoughts on his senior season and LSU's impressive run.
Tiger BlitzYesterday at 3:55 AM